Cardiotoxicity of 5-fluorouracil - A case report.
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چکیده
منابع مشابه
5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
BACKGROUND Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. CASE PRESENTATION A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highli...
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Pyrimidine analogues such as 5-fluorouracil (5-FU) are widely used in adjuvant and palliative treatment of various solid tumours. However, their administration may be associated with severe adverse events such as myelosuppression, mucositis or cardiotoxicity. Cardiotoxicity is a relatively rare event but its fatal outcomes occur at a rate of 2.2-13.3%. Since 5-fluorouracil is widely used in med...
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BACKGROUND 5-Fluorouracil (5-FU) is the backbone of chemotherapy regimens approved for treatment of colorectal cancer. The incidence of cardiotoxicity associated with 5-FU ranges from 1.5% to 18%; 48% as anginal symptoms and 2% as cardiogenic shock. Cardiotoxicity is unpredictable and no alternative chemotherapeutics have been defined so far. PATIENTS AND METHODS We present a case series of s...
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5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk...
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ژورنال
عنوان ژورنال: Practica Oto-Rhino-Laryngologica
سال: 1988
ISSN: 1884-4545,0032-6313
DOI: 10.5631/jibirin.81.1333